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WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a rare condition where the body’s immune system doesn’t function properly and has trouble fighting infections. WHIM syndrome causes low levels of white blood cells in the bloodstream, which can lead to weakened immunity.
XOLREMDI is an oral prescription medicine FDA approved for use in people 12 years of age and older with WHIM (warts, hypogammaglobulinemia, infections and myelokathexis) syndrome.
XOLREMDI targets the CXCR4 pathway, which does not work properly in people with WHIM syndrome, to help white blood cells move from the bone marrow into the bloodstream where they can help fight infections.
In patients with certain risk factors, XOLREMDI may cause a serious heart rhythm problem (QT prolongation). The most common side effects of XOLREMDI include: low platelet count (thrombocytopenia), rash (including a kind called pityriasis), nasal irritation, nosebleeds, vomiting, and dizziness. These are not all the possible side effects of XOLREMDI. Talk to your healthcare provider if you have any questions about the possible side effects of XOLREMDI or if you experience any side effects while taking XOLREMDI that bother you or do not go away.
XOLREMDI increases the number of certain white blood cells (neutrophils and lymphocytes) circulating in the bloodstream. Talk to your healthcare provider to evaluate how you're doing on XOLREMDI.
Tell your healthcare provider about other medicines you are taking or want to take while taking XOLREMDI. XOLREMDI may affect the way other medicines work, and other medicines may affect how XOLREMDI works. It is especially important to tell your healthcare provider if you are taking a type of pain medicine called opioids or any medications for depression or other mental health disorders, abnormal heart rhythm, high blood pressure, or breast cancer.
If you and your healthcare provider are considering XOLREMDI, it is important to discuss any medications you are currently taking for WHIM syndrome. You should also make sure your healthcare provider is aware of all the prescription and over-the-counter medicines you take, as well as vitamins and herbal supplements, such as goldenseal and St. John's Wort.
Your cost will depend on your insurance coverage. Talk to your healthcare provider about getting enrolled in X4Connect, a patient support program with Care Coordinators who can provide help with understanding insurance coverage and out-of-pocket costs, and finding financial support.
Consistency is key. Taking XOLREMDI daily, as prescribed, is an important part of managing your condition. Learn more about the XOLREMDI study results here, or speak with your healthcare provider.
Daily alerts can help you stay on track. Set up reminders here.
Taking XOLREMDI along with food is likely to reduce how much of the drug is absorbed by your body. Take XOLREMDI as prescribed, on an empty stomach after an overnight fast and at least 30 minutes before eating.
The bottle for XOLREMDI is designed to protect the medication from moisture. XOLREMDI should be stored in the refrigerator in the original bottle with the top tightly closed.
To maintain stability, XOLREMDI must be stored at the standard refrigerator temperature of 36°F to 46°F (2°C to 8°C). Talk to your healthcare provider for specific instructions.
Your healthcare provider can help answer questions related to XOLREMDI treatment and can get you enrolled in X4Connect for financial assistance options.
If you miss a dose of XOLREMDI, take your next dose as scheduled the following morning, on an empty stomach. Do not take more than one XOLREMDI dose each day.
You can take a trip and stay on track with XOLREMDI. Plan ahead and talk to your healthcare team about how to transport and store XOLREMDI while traveling.
What should I tell my healthcare provider before taking XOLREMDI?
Before taking XOLREMDI, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant. XOLREMDI can harm your unborn baby. You must use a reliable method of birth control (contraception) during treatment and for three weeks after you stop taking XOLREMDI. Talk to your healthcare provider about options for effective birth control and the best way to feed your baby while taking XOLREMDI.
Tell your healthcare provider if you have kidney, liver, or heart problems.
Tell your healthcare provider about all the prescription and over-the-counter medicines you take, as well as vitamins and herbal supplements, such as goldenseal and St. John's Wort. XOLREMDI may affect the way other medicines work, and other medicines may affect how XOLREMDI works. It is especially important to tell your healthcare provider if you are taking a type of pain medicine called opioids or any medications for depression or other mental health disorders, abnormal heart rhythm, high blood pressure, or breast cancer. If you are taking these medications while you are taking XOLREMDI, your healthcare provider may stop XOLREMDI, decide to change your dose, or monitor you more closely.
You should not eat grapefruit or drink grapefruit juice while taking XOLREMDI.
What are the possible side effects of XOLREMDI?
In patients with certain risk factors, XOLREMDI may cause a serious heart rhythm problem (QT prolongation).
The most common side effects of XOLREMDI are low platelet count (thrombocytopenia), rash (including a kind of rash called pityriasis), nasal irritation, nosebleeds, vomiting, and dizziness.
These are not all the possible side effects of XOLREMDI. Tell your healthcare provider if you have any side effects that bother you or do not go away. For more information, ask your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA at www.fda.gov/medwatch or by calling 1-800-FDA-1088. You may also call X4 Pharmaceuticals at 1-866-MED-X4MI (1-866-633-9464).
XOLREMDI is an oral prescription medicine used in people 12 years of age and older with WHIM (warts, hypogammaglobulinemia, infections and myelokathexis) syndrome to increase the number of certain white blood cells (neutrophils and lymphocytes) circulating in the bloodstream.
Please see the full Prescribing Information for XOLREMDI.
