WHIM Syndrome Increases Your Infection Risk
WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a rare condition where the body’s immune system doesn’t function properly and has trouble fighting infections. WHIM syndrome causes low levels of white blood cells in the bloodstream, which can lead to weakened immunity.
White blood cells are an essential part of the immune system, helping your body defend against bacteria and viruses.
WHIM syndrome causes low levels of white blood cells—including neutrophils and lymphocytes—in the bloodstream, making you especially vulnerable to frequent and possibly serious infections.
Increasing white blood cell levels in your bloodstream may help improve immune function, helping your body fight infections.
When white blood cell levels in your bloodstream are low, your risk of infection goes up.
Therefore, increasing the amount of white blood cells in your bloodstream can help your body fight infections by improving immune function.
The Underlying Cause of WHIM Syndrome
The CXCR4 pathway helps white blood cells move from the bone marrow into the bloodstream, where they can help fight infections. In WHIM syndrome, this pathway does not work properly, preventing most white blood cells from leaving the bone marrow. This is the underlying cause of the condition.
HEALTHY—CXCR4 Pathway Is Working Properly
White blood cells, like neutrophils and lymphocytes, move normally into the bloodstream.
IN WHIM SYNDROME—CXCR4 Pathway Is Not Working Properly
Many white blood cells get stuck in the bone marrow.
With low levels of white blood cells in the bloodstream, the body is immunocompromised and vulnerable to infections.
XOLREMDI is the first FDA-approved treatment that specifically targets the underlying cause of WHIM syndrome
Ask Your Healthcare Provider About XOLREMDI
This resource can help guide your discussion about XOLREMDI with your healthcare provider
IMPORTANT SAFETY INFORMATION
What should I tell my healthcare provider before taking XOLREMDI?
Before taking XOLREMDI, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant. XOLREMDI can harm your unborn baby. You must use a reliable method of birth control (contraception) during treatment and for three weeks after you stop taking XOLREMDI. Talk to your healthcare provider about options for effective birth control and the best way to feed your baby while taking XOLREMDI.
Tell your healthcare provider if you have kidney, liver, or heart problems.
Tell your healthcare provider about all the prescription and over-the-counter medicines you take, as well as vitamins and herbal supplements, such as goldenseal and St. John's Wort. XOLREMDI may affect the way other medicines work, and other medicines may affect how XOLREMDI works. It is especially important to tell your healthcare provider if you are taking a type of pain medicine called opioids or any medications for depression or other mental health disorders, abnormal heart rhythm, high blood pressure, or breast cancer. If you are taking these medications while you are taking XOLREMDI, your healthcare provider may stop XOLREMDI, decide to change your dose, or monitor you more closely.
You should not eat grapefruit or drink grapefruit juice while taking XOLREMDI.
What are the possible side effects of XOLREMDI?
In patients with certain risk factors, XOLREMDI may cause a serious heart rhythm problem (QT prolongation).
The most common side effects of XOLREMDI are low platelet count (thrombocytopenia), rash (including a kind of rash called pityriasis), nasal irritation, nosebleeds, vomiting, and dizziness.
These are not all the possible side effects of XOLREMDI. Tell your healthcare provider if you have any side effects that bother you or do not go away. For more information, ask your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA at www.fda.gov/medwatch or by calling 1-800-FDA-1088. You may also call X4 Pharmaceuticals at 1-866-MED-X4MI (1-866-633-9464).
WHAT IS XOLREMDITM (mavorixafor)?
XOLREMDI is an oral prescription medicine used in people 12 years of age and older with WHIM (warts, hypogammaglobulinemia, infections and myelokathexis) syndrome to increase the number of certain white blood cells (neutrophils and lymphocytes) circulating in the bloodstream.
Please see the full Prescribing Information for XOLREMDI.